Dynamic Model of Andrographolide Therapy for COVID-19

Dynamic Model of Andrographolide Therapy for COVID-19

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Andrographis paniculate extract (APE) has been used as a Thailand traditional medicine owing to andrographolide which is effective for the viral clearance and prevention of disease 5326058hx progression.Several viral infections have been treated with APE, including SARS-CoV-2.The recommended dosage is 180 mg three times a day.We constructed a mathematical viral dynamic model of the SARS-CoV-2 model with andrographolide therapy by different doses.

The pharmacokinetic/pharmacodynamic (PK/PD) model reduces the duration of viral clearance with a dose of 60 mg per day.Moreover, APE improved baseball scoreboards for sale the therapeutic efficacy of COVID-19 therapy.